Hypersensitivity to Proton Pump Inhibitors: Lansoprasol-induced Kounis Syndrome

Authors

  • Georgios Ch. Almpanis
  • Simos P. Siachos
  • Nicholas P. Vlahos
  • Andreas Mazarakis

DOI:

https://doi.org/10.2015/hc.v3i1%20sup.116

Keywords:

allergic myocardial, infarction, Kounis syndrome, lansoprazol, proton pump inhibitors

Abstract

Proton pump inhibitors are commonly used in clinical practice for the treatment of peptic ulcer disease and gastro-esophageal reflux and are well tolerated by the patients. Their use is rarely associated with hypersensitivity and anaphylactic reactions.According to the reports in the Uppsala Monitoring Center database the frequency of hypersensitivity reactions out of all reported adverse reactions for proton pump inhibitors and H2-histamine receptor antagonists were between 0.2% and 0.7%. A few cases of hypersensitivity to lansoprazole have been reported. Herein, we report a patient who developed Kounis syndrome after taking 40 mg of lansoprazole. To our knowledge, this is the first report of Kounis syndrome associated with lansoprazole administration in the world literature.

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Issue

Vol. 3 No. 1 sup (2008)

Section

Athens Cardiology Update 2008

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