The Role of Fluorodeoxyglucose Standardized Uptake Value in Diagnosis, Staging and Restaging of Non-Small Cell Lung Cancer
Keywords:Fluorodeoxyglucose, positron emission tomography, lung cancer, standardized uptake value, non-small lung cancer
Molecular imaging with [18F]-fluorodeoxyglucose positron emission tomography / computed tomography ([18F]FDG-PET/CT) has become part of the standard of care in oncology patients. In oncology, the quantification for the analysis of PET data is an important tool for tumor diagnosis, staging, determination of prognosis and assessment of response to treatment. In clinical practice, standardized uptake value (SUV), a semi-quantitative parameter, is the most widely used parameter for the analysis of tracer uptake in PET imaging. The purpose of this review is to evaluate the role of the SUV in diagnosis, staging and restaging of the lung cancer, and also to establish the differences in [18F]FDG uptake across different histopathological subtypes of non-small lung cancer (NSCLC). Furthermore another purpose of the study is to gather and compare the SUVmax cut-off values, in differentiating benign from malignant lesions, in assessing the response to treatment and finally to identify the optimal threshold.
LicenseAuthors who publish with this journal agree to the following terms:
a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).