Hypersensitivity to Proton Pump Inhibitors: Lansoprazole-Induced Kounis Syndrome
DOI:
https://doi.org/10.2015/hc.v3i4.294Abstract
Proton pump inhibitors are commonly used in clinical practice for the treatment of peptic ulcer disease and gastro-esophageal reflux and are well tolerated by patients. Their use is rarely associated with hypersensitivity and anaphylactic reactions. According to the reports in the Uppsala Monitoring Center database the frequency of hypersensitivity reactions among all reported adverse reactions for proton pump inhibitors and H2-histamine receptor antagonists were between 0.2% and 0.7%. A few cases of hypersensitivity to lansoprazole have been reported. Herein, we report a patient who developed Kounis syndrome after taking 40 mg of lansoprazole. To our knowledge, this is the first report of Kounis syndrome associated with lansoprazole administration in the world literature.Downloads
Issue
Section
License
Authors who publish with this journal agree to the following terms:a. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
b. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
c. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
