Thrombophilia and Other Conditions Associated With Acute Cardiovascular Syndromes

Abstract

Although the classical risk factors are found in the majority of patients with acute coronary syndromes, in a good percentage, particularly young patients, known modifiable risk factors are not present. In this subgroup of patients with acute coronary events, thrombophilia or hypercoagulable states have been suspected and several genetic variants (polymorphisms) have been found in genes related to coagulation proteins, fibrinolytic system, platelet receptors, homocysteine metabolism, platelet receptors, endothelial dysfunction, and abnormal blood flow. Angioproliferative disorders have also been reported as associated with non-atherosclerotic coronary disease. In this brief overview, such nonclassical risk factors and causes of coronary events are discussed.