Ticagrelor: a Novel P2Y12 Platelet Receptor Antagonist
DOI:
https://doi.org/10.2015/hc.v5i2.220Abstract
Blockade of platelet adenosine-diphosphate (ADP) receptors has been established as a key therapeutic strategy in cardiovascular disease. Among the thienopyridines, clopidogrel decreases ischemic outcome in patients who present with acute coronary syndromes and the more potent prasugrel has been demonstrated to be superior to clopidogrel in patients who are scheduled to undergo percutaneous coronary intervention. However, the antiplatelet potency is also associated with an increased risk of bleeding complications, and the irreversible ADP receptor antagonism has potential implications especially in the setting of coronary by-pass operation. Ticagrelor is a new reversible antagonist of the P2Y12 receptor, which seems to be more effective and at the same time equally safe to the so far established antiplatelet regimens. This article reviews the current data on this novel compound focusing on its advantageous pharmacology and the clinical results provided by the first phase IIb and III trials.Downloads
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