Long Term Beneficial Effects of Good Glycemic Control on Macrovascular Disease: Results from UKPDS 10-Year Post Trial Monitoring

Authors

  • Socrates Pastromas First Cardiology Department, Evagelismos Hospital, Athens, Greece
  • Spyridon Koulouris First Cardiology Department, Evagelismos Hospital, Athens, Greece
  • Antonis S. Manolis First Cardiology Department, Evagelismos Hospital, Athens, Greece

DOI:

https://doi.org/10.2015/hc.v5i4.215

Keywords:

diabetes, macrovascular disease, glycemic control, cardiovascular disease

Abstract

Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus. The impact of tight glycemic control in the mortality has been investigated in large randomized clinical trials. The data are controversial, as some trials (ACCORD, ADVANCE and VADT) have found that intensive glycemic control either has no impact on cardiovascular outcomes or even worsens them. On the other hand, results of the 10-year follow-up of the UKPDS study suggest that tight glycemic control of younger, newly diagnosed patients with type 2 diabetes may have long term beneficial cardiovascular effects. All these data have led to the adoption of clinical guidelines suggesting a different strategy according to the patient’s age and duration of diabetes.

Author Biography

Socrates Pastromas, First Cardiology Department, Evagelismos Hospital, Athens, Greece

Cardiology

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Published

2010-09-01

Issue

Section

EDITORIAL