Rosacea-Like Demodicosis Induced by Topical Pimecrolimus: Immunohistochemical Evaluation of Inflammatory Infiltrate

Authors

  • Efi Pasmatzi
  • Maria Melachrinou
  • Alexandra Monastirli
  • Anastasia Tzouma
  • Dionysios Tsambaos

DOI:

https://doi.org/10.2015/hc.v4i4.170

Abstract

We present a 48-year-old female patient who developed rosacea-like demodicosis after seven days of?  topical application of?  1% pimecrolimus cream. The inflammatory infiltrate in the lesions was mainly composed of T-cells with a CD4+/CD8+ ratio = 0.33; B-cells (CD20+) and NK-cells (CD56+) were not detected. Large numbers of (CD68+) histiocytes were demonstrated, whereas the number of Langerhans cells (CD1a+) revealed no significant alteration. The reduced CD4+:CD8+ ratio may have led to a modification of follicular microenvironment favouring the excessive proliferation of Demodex mites, who triggered a presently unknown sequence of events leading to the development of pimecrolimus-induced rosacea-like demodicosis. ? 

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Author Biographies

Efi Pasmatzi

Department of Dermatology, School of Medicine, University of Patras

Maria Melachrinou

Department of Pathology, School of Medicine, University of Patras

Alexandra Monastirli

Department of Dermatology, School of Medicine, University of Patras

Anastasia Tzouma

Department of Dermatology, School of Medicine, University of Patras

Dionysios Tsambaos

Department of Dermatology, School of Medicine, University of Patras

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Published

2009-12-24

Issue

Vol. 4 No. 4 (2009)

Section

CASE REPORTS

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